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Human parvovirus B19 in cord blood of premature infants

M Koga1, T Matsuoka, K Katayama

  • 1Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan.

American Journal of Perinatology
|September 12, 2001
PubMed

Insights

Human parvovirus B19 infection is unlikely to cause premature birth. Testing umbilical cord blood from premature infants found no evidence of parvovirus B19 infection, suggesting it is not a cause of preterm birth.

Area of Science:

  • Obstetrics and Gynecology
  • Virology
  • Neonatology

Background:

  • Human parvovirus B19 is a common virus that can infect pregnant women.
  • Intrauterine infection with parvovirus B19 has been suspected as a cause of adverse pregnancy outcomes, including premature birth.

Purpose of the Study:

  • To investigate the association between intrauterine parvovirus B19 infection and premature birth.
  • To evaluate the presence of parvovirus B19 antibodies and DNA in umbilical cord blood of premature infants.

Main Methods:

  • Enzyme-linked immunosorbent assays (ELISA) were used to detect B19-specific IgM antibodies.
  • Polymerase chain reaction (PCR) assays were performed to detect parvovirus B19 DNA.
  • Samples were obtained from the umbilical cord blood of 76 premature infants.

Main Results:

  • No parvovirus B19 DNA was detected in any of the umbilical cord blood samples.
  • No samples tested positive for anti-parvovirus B19 IgM antibodies.
  • The study found no evidence of intrauterine parvovirus B19 infection in the cohort.

Conclusions:

  • Intrauterine parvovirus B19 infection is unlikely to be a significant cause of premature birth.
  • Further research may be needed to fully understand the role of parvovirus B19 in pregnancy complications.

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