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Combination thrombolytic and anticoagulant therapy for bilateral renal vein thrombosis in a premature infant

N Weinschenk1, M Pelidis, J Fiascone

  • 1Division of Newborn Medicine, Department of Pediatrics, Floating Hospital for Children, Tufts University School of Medicine, Boston, Massachusetts, USA.

American Journal of Perinatology
|September 12, 2001
PubMed

Insights

A premature infant treated for renal vein thrombosis experienced cerebral hemorrhage. This case highlights the need for caution and further research on thrombolytic and anticoagulation therapies in newborns.

Area of Science:

  • Neonatal Medicine
  • Pediatric Nephrology
  • Thrombosis Research

Background:

  • Premature infants are susceptible to venous thrombosis, including renal vein thrombosis.
  • Renal vein thrombosis can lead to acute kidney injury and renal failure in neonates.
  • Thrombolytic and anticoagulation therapies are increasingly used for venous thrombosis.

Observation:

  • A 1-month-old premature infant presented with bilateral renal vein thrombosis and renal failure.
  • The infant received treatment with recombinant tissue plasminogen activator and heparin sulfate.
  • The therapy resulted in intraventricular and intraparenchymal cerebral hemorrhage.

Findings:

  • The combination therapy did not resolve the renal vein thrombosis.
  • Cerebral hemorrhage occurred as a complication of the treatment.
  • This case demonstrates a severe adverse event in a neonate.

Implications:

  • Caution is advised when using thrombolytic and anticoagulation therapies in premature infants.
  • Further studies are needed to evaluate the safety and efficacy of these treatments in neonates.
  • Risk-benefit assessment is crucial for managing neonatal thrombosis.

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