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Creatine phosphokinase after submaximal physical exercise in untrained individuals
Acta Medica Scandinavica
|June 1, 1975
Summary
Submaximal exercise minimally elevates serum creatine phosphokinase (CPK) levels, rarely exceeding normal limits. This suggests physical exertion before acute myocardial infarction (AMI) symptoms is unlikely to interfere with CPK diagnostic accuracy.
Area of Science:
- Clinical Biochemistry
- Cardiology
- Sports Medicine
Background:
- Serum creatine phosphokinase (CPK) is a biomarker used in diagnosing acute myocardial infarction (AMI).
- Physical exercise can also increase serum CPK levels, potentially confounding AMI diagnosis.
Purpose of the Study:
- To investigate the impact of submaximal physical exercise on serum CPK levels in untrained individuals.
- To determine if exercise-induced CPK elevation interferes with the diagnostic window for AMI.
Main Methods:
- Serial serum CPK measurements were taken before and up to 49 hours after submaximal exercise in 17 untrained adults (mean age 50).
- Exercise-induced CPK increases were compared to typical CPK elevations observed in acute myocardial infarction (AMI) patients.
Main Results:
- Maximal CPK increase after exercise was 32 mU/ml (73%), with only one individual exceeding the normal limit (150 mU/ml).
- In contrast, AMI patients showed significantly higher CPK elevations, ranging from 101 mU/ml (133%) to 2,260 mU/ml (3,790%), with a mean of 900 mU/ml (1,184%).
- The peak CPK elevation in AMI occurs within the same timeframe as post-exercise elevations.
Conclusions:
- Submaximal physical exercise causes a modest, transient increase in serum CPK that typically remains within normal diagnostic limits.
- Heavy, short-duration physical work preceding acute myocardial infarction symptoms is unlikely to significantly impair AMI diagnosis using CPK levels.