Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Immunologic problems in vascular homografts].

M D'Addato1, M Mirelli

  • 1Sezione di Chirurgia Vascolare, Dipartimento di Scienze Chirurgiche e Anestesiologiche, Università degli Studi di Bologna.

Annali Italiani Di Chirurgia
|September 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Smooth muscle cell injury after cryopreservation of human thoracic aortas.

Cryobiology·2006
Same author

Vascular tissue banking: state of the art.

Transplantation proceedings·2005
Same author

Fresh and cryopreserved arterial homografts: immunological and clinical results.

Transplantation proceedings·2005
Same author

Effects of defibrotide in patients with chronic deep insufficiency. The PROVEDIS study.

International angiology : a journal of the International Union of Angiology·2004
Same author

[Thoraco-abdominal aneurysms of type IV].

Annali italiani di chirurgia·2004
Same author

Ruptured pancreaticoduodenal artery aneurysm. A case report and review of the literature.

The Journal of cardiovascular surgery·2004
Same journal

Comparison of Small-Incision Tension-Free Mesh Repair With Scrotal Drainage and Laparoscopic Transabdominal Preperitoneal Repair for Inguinal Hernia: A Retrospective Cohort Study.

Annali italiani di chirurgia·2026
Same journal

Phyllodes Tumors: From National Guidelines to European Evidence and Collaboration.

Annali italiani di chirurgia·2026
Same journal

Anorectal Melanoma Management Evolution: A Narrative Review.

Annali italiani di chirurgia·2026
Same journal

Correlation and Responsiveness of Objective and Subjective Measures in Evaluating Periorbital Swelling After Upper Blepharoplasty: A Retrospective Study Using 3D Stereophotography and Visual Analogue Scale.

Annali italiani di chirurgia·2026
Same journal

Colonic Continuity After Splenic Flexure Resection: Does the Orientation of the Anastomosis Matter? A Retrospective Cohort Study.

Annali italiani di chirurgia·2026
Same journal

Aortic Repair in Landing Zone 2: From Chimney Technique to Branched Graft.

Annali italiani di chirurgia·2026
See all related articles

Fresh arterial homografts trigger a strong immune response in recipients. Managing this involves ABO compatibility, cross-matching, and immunosuppression to reduce graft antigenicity.

Area of Science:

  • Immunology
  • Vascular Surgery
  • Transplantation Science

Context:

  • Fresh arterial homografts are inherently immunogenic, eliciting significant immune responses in recipients.
  • The immune response involves both cellular (lymphocytotoxic) and humoral (antibody) components, which are correlated.
  • Arterial homograft transplantation mirrors the chronic rejection seen in solid-organ allografts.

Purpose:

  • To explore the immunogenicity of fresh arterial homografts.
  • To understand the cellular and humoral immune responses to arterial allografts.
  • To identify strategies for mitigating immune rejection in arterial transplantation.

Summary:

  • Arterial homografts induce a potent, donor-specific immune response in recipients, characterized by initial cellular and later humoral reactions.

Related Experiment Videos

  • Immunosuppressive therapy can reduce this immune reaction, but its effectiveness is dose-dependent.
  • Key considerations for arterial transplantation include ABO compatibility, negative crossmatch, and pre-transplant strategies to decrease homograft antigenicity.

    • Impact:

    • Highlights the critical need for immunological compatibility in arterial transplantation.
    • Emphasizes the role of immunosuppression and pre-transplant homograft modification in improving graft survival.
    • Provides a foundation for developing improved protocols to minimize immune rejection in vascular allografts.