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Gastrooesophageal reflux in infants and children in north India

S De1, K Rajeshwari, K K Kalra

  • 1Department of Paediatrics, Division of Paediatric Gastroenterology, Maulana Azad Medical College, Department of Pathology, G.B. Pant Hospital, New Delhi 110 002, India.

Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
|September 13, 2001
PubMed

Insights

Gastroesophageal reflux disease (GERD) is common in infants under two years old, with 10% showing symptoms. Evaluation is recommended for regurgitation beyond six months, with endoscopy confirming reflux esophagitis in over half of suspected cases.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Clinical Research

Background:

  • Gastroesophageal reflux disease (GERD) is a common condition in infants.
  • Accurate diagnosis relies on symptom assessment and objective measures.
  • Understanding GERD prevalence in young children is crucial for timely intervention.

Purpose of the Study:

  • To determine the prevalence of GERD in infants aged 1 month to 2 years using symptom profiles.
  • To evaluate the utility of the I-GERD score in identifying GERD in this age group.
  • To assess the diagnostic yield of upper gastrointestinal endoscopy and esophageal biopsy.

Main Methods:

  • A cohort of 602 infants (1 month to 2 years) was recruited.
  • The I-GERD questionnaire assessed symptom profiles, with scores > 5 indicating likely GERD.
  • Upper GI endoscopy and esophageal biopsy were performed in select cases.

Main Results:

  • 10% (61/602) of infants had an I-GERD score suggestive of GERD.
  • Regurgitation was common, but higher scores were more frequent in older infants with regurgitation.
  • Endoscopy revealed esophagitis in 51.6% (16/31) and biopsy confirmed it in 92% (23/25) of cases.

Conclusions:

  • GERD is prevalent in infants under two years, identifiable via symptom evaluation (I-GERD score).
  • Persistent regurgitation beyond six months warrants further investigation.
  • Endoscopy and biopsy are valuable tools for diagnosing reflux esophagitis in symptomatic infants.
Abstract

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