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Diffusion tensor trace mapping in normal adult brain using single-shot EPI technique. A methodological study of the
Z G Chen1, T Q Li, T Hindmarsh
1Karolinska MR Research Center, Department of Neuroradiology, Karolinska Hospital, Stockholm, Sweden.
Acta Radiologica (Stockholm, Sweden : 1987)
|September 13, 2001
Summary
This study found that the average diffusion coefficient in the adult brain increases with age, particularly after 40. Researchers recommend consistent experimental settings for accurate diffusion quantification in aging brain studies.
Area of Science:
- Neuroimaging
- Biophysics
- Radiology
Background:
- Brain aging is associated with structural and functional changes.
- Diffusion tensor imaging (DTI) is a valuable tool for assessing brain microstructure.
- Quantifying age-related changes in brain diffusion requires robust methodologies.
Purpose of the Study:
- To quantify age-related changes in average diffusion coefficient in the normal adult brain.
- To investigate methodological influences on diffusion quantification.
- To establish normative data for brain diffusion metrics across the adult lifespan.
Main Methods:
- Diffusion-weighted echo-planar imaging was performed on 54 healthy subjects (20-79 years) using a 1.5-T MRI scanner.
- Orientation-independent diffusion tensor trace maps were generated using a tetrahedral gradient pattern.
- Global and tissue averages of diffusion coefficients were analyzed via histogram analysis of diffusion coefficient distribution.
Main Results:
- A significant positive correlation was observed between age and both global and tissue average diffusion coefficients (p<0.03).
- The global average diffusion coefficient increased by approximately 3% per decade after age 40.
- The tissue average diffusion coefficient increased by approximately 1% per decade after age 40.
Conclusions:
- Age-related increases in average diffusion coefficient align with known structural changes in the aging brain.
- Consistent experimental parameters are crucial for reliable diffusion coefficient quantification and inter-subject comparisons.
- This study provides quantitative insights into normal brain aging using diffusion tensor trace mapping.