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Relaxin affects the dentofacial sutural tissues.

Jonathan L. Nicozisis1, Hyun-Duck Nah-Cederquist, Orhan C. Tuncay

  • 1Princeton Professional Park, Suite B-12, 601 Ewing St., Princeton, NJ 08540; University of Pennsylvania, Department of Biochemistry, School of Dental Medicine and Department of Orthodontics, Temple University, Philadelphia, PA; Department of Orthodontics, Temple University, Philadelphia, PA.

Clinical Orthodontics and Research
|September 13, 2001
PubMed
Summary

The hormone relaxin may aid orthodontic treatments by altering connective tissue in craniofacial sutures and periodontal ligament. This study found relaxin present in sutures and affecting tissue structure and protease activity.

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Area of Science:

  • Connective tissue biology
  • Endocrinology
  • Craniofacial biology

Background:

  • Relaxin, a hormone produced during pregnancy, softens connective tissues.
  • Its effects on collagen and fibroblastic activity are known in various body regions.
  • Potential roles in craniofacial and periodontal tissues are unexplored.

Purpose of the Study:

  • To investigate relaxin's presence in craniofacial sutures.
  • To assess relaxin's impact on suture and periodontal tissue integrity.
  • To evaluate relaxin's effect on protease activity in these tissues.

Main Methods:

  • Immunohistochemistry to detect relaxin in sutures.
  • Tissue culture experiments with relaxin (250 and 500 ng/ml) for 24 hours.
  • Histological analysis of collagen arrangement and protease activity assays.

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Main Results:

  • Relaxin was detected within cranial sutures.
  • Histology showed altered collagen fibril organization in the periodontal ligament (PDL).
  • Relaxin-treated samples exhibited increased protease activity.

Conclusions:

  • Relaxin is present in craniofacial sutures and modulates connective tissue properties.
  • It may serve as an adjunct in orthodontic therapy for tissue remodeling.
  • Potential applications include post-surgical soft tissue adaptation and improved periodontal stability.