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Updated: Aug 11, 2026
06:39
Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
Enhanced platelet aggregation in the coronary circulation after coronary spasm
S Miyamoto1, H Ogawa, H Soejima
1Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto City 860-8556, Japan.
Thrombosis Research
|September 13, 2001
Summary
Coronary artery spasm triggers small platelet aggregate formation in the heart
Area of Science:
- Cardiology
- Hematology
- Vascular Biology
Background:
- Conventional methods fail to detect small platelet aggregates.
- The role of coronary spasm in platelet aggregation is unclear.
Purpose of the Study:
- Investigate platelet aggregation, particularly small aggregates, in coronary spastic angina.
- Determine if coronary spasm induces platelet aggregation in coronary circulation.
Main Methods:
- Utilized a novel laser light scattering platelet aggregometer.
- Measured small platelet aggregates in coronary sinus and aortic root.
- Induced coronary spasm with acetylcholine in patients with coronary spastic angina and chest pain syndrome.
- Induced acute myocardial ischemia via atrial pacing in stable exertional angina patients.
Main Results:
- Significant increase in small platelet aggregates in both coronary sinus and aortic root post-spasm in coronary spastic angina patients.
- Coronary sinus-arterial difference in small platelet aggregates significantly increased after spasm.
- No significant changes observed in stable exertional angina or chest pain syndrome groups.
Conclusions:
- Acute myocardial ischemia induced by coronary spasm causes platelet aggregation within the coronary circulation.
- Small platelet aggregates play a role in coronary artery spasm events.
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