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Selection of a high-affinity DNA pool for a bZip protein with an out-of-phase alignment of the basic region relative

Y Lee1, D G Gurnon, J J Hollenbeck

  • 1Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, IN 47405-7102, USA.

Bioorganic & Medicinal Chemistry
|September 13, 2001
PubMed

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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...