Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural determinants of glomerular permeability.

W M Deen1, M J Lazzara, B D Myers

  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, USA. wmdeen@mit.edu

American Journal of Physiology. Renal Physiology
|September 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying Determinants of EGFR-Targeted Therapeutic Biochemical Efficacy Using Computational Modeling.

CPT: pharmacometrics & systems pharmacology·2014
Same author

Imaging and elemental mapping of biological specimens with a dual-EDS dedicated scanning transmission electron microscope.

Ultramicroscopy·2013
Same author

Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations.

Oncogene·2012
Same author

Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane.

Molecular and cellular biology·2011
Same author

Serum relaxin levels and kidney function in late pregnancy with or without preeclampsia.

Clinical nephrology·2011
Same author

Course of preeclamptic glomerular injury after delivery.

American journal of physiology. Renal physiology·2008
Same journal

Blood Pressure Responses to Dietary Salt in Renin-Deficient Dahl Salt-Sensitive Rats.

American journal of physiology. Renal physiology·2026
Same journal

Cytokine Profiles in Patients with Chronic Kidney Disease and Low Sexual Function.

American journal of physiology. Renal physiology·2026
Same journal

Renovascular disease induces functionally relevant, locus-specific alterations to DNA methylation and hydroxymethylation in swine scattered tubular-like cells.

American journal of physiology. Renal physiology·2026
Same journal

Nitrite Protects Against Cardiac Surgery-Associated Acute Kidney Injury via Inflammation Suppression: Insights from a Rat Cardiopulmonary Bypass Model.

American journal of physiology. Renal physiology·2026
Same journal

Etanercept attenuates TNFα-mediated kidney injury in a rat model of brain death kidney donation.

American journal of physiology. Renal physiology·2026
Same journal

Phosphorylation of aquaporin-2 at serine 269 in urinary extracellular vesicles reflects renal vasopressin activity in rats.

American journal of physiology. Renal physiology·2026
See all related articles

The glomerular capillary wall

Area of Science:

  • Nephrology
  • Renal Physiology
  • Biophysics

Background:

  • The glomerular capillary wall's structure dictates its function in kidney filtration.
  • Understanding this structure-function relationship is key to diagnosing and treating kidney diseases.

Purpose of the Study:

  • To review recent advancements in correlating glomerular capillary wall structure with its functional properties.
  • To analyze hydrodynamic models and experimental data on water and macromolecule filtration.

Main Methods:

  • Review of existing literature and hydrodynamic modeling.
  • Integration of morphometric data with water flow measurements in isolated glomerular basement membrane (GBM).
  • Analysis of macromolecule filtration models and experimental findings on size and charge selectivity.

Related Experiment Videos

Main Results:

  • Hydrodynamic models predict hydraulic permeabilities consistent with in vivo measurements.
  • GBM resistance significantly impacts water flow, influenced by cellular blockage.
  • Filtration slit frequency is a crucial determinant of hydraulic permeability.
  • Glomerular size selectivity is primarily governed by cellular layers, not GBM.
  • Evidence supports a role for charge in restricting albumin movement, with albumin potentially affecting other macromolecule sieving coefficients.

Conclusions:

  • The arrangement of fenestrated endothelium, GBM, and filtration slits creates a complex filtration barrier.
  • Hydraulic resistances are additive, but macromolecule sieving coefficients are multiplicative.
  • Further research is needed to clarify the roles of the endothelial glycocalyx and slit diaphragm, and the nanostructural basis of GBM permeability.