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Updated: Oct 4, 2026
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Mouse cytokine profiles associated with Brucella abortus RB51 vaccination or B. abortus 2308 infection
P Pasquali1, R Adone, L C Gasbarre
1Laboratory of Veterinary Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy. pasquali@iss.it
Abstract:
This study indicated that mice immunized with Brucella abortus RB51 bacteria and subsequently challenged with B. abortus 2308 were protected from reinfection. After vaccination, both Th1 and Th2 cytokine patterns were observed. Of those, the early production of gamma interferon seems to have the prominent role in inducing an immunologically based protection.
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