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Updated: Aug 5, 2026
07:46
Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
Published on: June 4, 2012
Treatment of Staphylococcus aureus endocarditis using moxifloxacin
A W Berrington1, R J Koerner, J D Perry
1Department of Medical Microbiology, Freeman Hospital, Newcastle upon Tyne, UK. andrew@corstopitum.freeserve.co.uk
International Journal of Medical Microbiology : IJMM
|September 14, 2001
Summary
Conventional staphylococcal endocarditis treatment is challenging. Adding moxifloxacin, a new quinolone antibiotic, proved curative in a patient resistant to standard therapies, offering a potential alternative for this serious infection.
Area of Science:
- Infectious Diseases
- Pharmacology
- Cardiology
Background:
- Staphylococcal endocarditis poses treatment challenges due to conventional therapy limitations, including inpatient requirements and potential toxicity.
- Newer quinolone antibiotics demonstrate good absorption, tolerability, and high activity, suggesting potential as therapeutic alternatives.
Observation:
- A patient with staphylococcal endocarditis did not respond to conventional treatment regimens.
- This case highlights a therapeutic challenge in managing resistant staphylococcal endocarditis.
Findings:
- The addition of moxifloxacin, an 8-methoxyquinolone, to the treatment regimen resulted in a curative outcome.
- Moxifloxacin demonstrated efficacy in a refractory case of staphylococcal endocarditis.
Implications:
- Moxifloxacin may represent a viable and effective alternative therapeutic option for difficult-to-treat staphylococcal endocarditis.
- This case supports further investigation into the role of novel quinolones in managing infective endocarditis.
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