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Related Experiment Videos

Circulating human antisperm antibodies recognize prostasomes.

C Allegrucci1, G Ronquist, B Ove Nilsson

  • 1Dipartimento di Biologia Cellulare e Molecolare, Universita di Perugia, Italy.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|September 14, 2001
PubMed
Summary
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Prostasomes, secreted by the prostate, may be a primary target for antisperm antibodies (ASA) causing infertility. This study found that infertile patients frequently have antibodies against prostasomes, suggesting their role in infertility.

Area of Science:

  • Immunology
  • Reproductive Biology
  • Urology

Background:

  • Naturally occurring antisperm antibodies (ASA) are a known cause of infertility.
  • The specific antigens targeted by ASA are often poorly understood.
  • Prostasomes, secreted by prostate cells, can interact with sperm.

Purpose of the Study:

  • To investigate whether prostasomes act as antigens for ASA.
  • To determine the prevalence of antiprostasome antibodies in infertile individuals.

Main Methods:

  • Examined reactivity of chicken antiprostasome antibodies with sperm via agglutination.
  • Analyzed serum from 20 infertile patients for ASA reactivity with sperm (flow cytometry) and prostasomes (ELISA).

Main Results:

Related Experiment Videos

  • Chicken antiprostasome antibodies induced sperm agglutination, similar to patient sera.
  • All tested infertile patients' sera contained IgG antibodies against prostasomes.

Conclusions:

  • Prostasomes are frequently targeted by ASA in infertile patients.
  • Prostasomes are likely a significant antigen contributing to ASA-induced infertility.