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Related Experiment Videos

Diabetic glomerulosclerosis without glucose intolerance.

D A Nash, P W Rogers, P C Langlinais

    The American Journal of Medicine
    |August 11, 1975
    PubMed
    Summary
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    Diabetic glomerulosclerosis can occur without overt carbohydrate intolerance. This study shows thickened glomerular and muscle capillary basement membranes in patients with suspected diabetes, suggesting a new diagnostic approach for diabetic microangiopathy.

    Area of Science:

    • Nephrology
    • Endocrinology
    • Pathology

    Background:

    • Diabetic microangiopathy pathophysiology is unclear, especially the role of carbohydrate intolerance.
    • Renal abnormalities suggestive of diabetic glomeruloscierosis can occur in patients without clinical carbohydrate intolerance.

    Purpose of the Study:

    • To investigate diabetic glomerulosclerosis in patients without overt carbohydrate intolerance.
    • To identify alternative diagnostic markers for diabetic nephropathy.

    Main Methods:

    • Analysis of renal biopsy specimens from four patients with suspected diabetes mellitus.
    • Measurement of glomerular and skeletal muscle capillary basement membrane thickness using latex microsphere technology.
    • Evaluation of clinical and familial history for carbohydrate intolerance and diabetes.

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    Main Results:

    • Patients exhibited diffuse glomerular capillary basement membrane thickening (mean 4,403 A vs. control 3,098 A) and skeletal muscle capillary basement membrane thickening (mean 1,510 A vs. control 961 A).
    • Renal pathology included efferent arteriolosclerosis and linear immunofluorescence without electron dense deposits.
    • Only two of four patients showed early intercapillary nodule formation.

    Conclusions:

    • Diabetic glomerulosclerosis may be diagnosed in the absence of clinical carbohydrate intolerance.
    • Glomerular and muscle capillary basement membrane thickening are significant indicators of diabetic nephropathy.
    • Latex microsphere technology offers a method to diagnose diffuse glomerular capillary basement membrane thickening.