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Updated: Jul 15, 2026

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
A novel catalytic pathway for perfluoroacyl peroxide synthesis
P A Krasutsky1, I V Kolomitsyn, R M Carlson
1Natural Resources Research Institute, Duluth, Minnesota 55811-1442, USA. pkrasuts@d.umn.edu
Abstract:
A new catalytic method for synthesis of bis(perfluoroacyl) peroxides (BPFAP) was elaborated by using hydrogen peroxide and perfluoroacyl anhydrides. The desired BPFAP were formed quantitatively in situ when perfluoroacyl anhydride was mixed with hydrogen peroxide (ratio > or = 2:1) in the presence of a catalytic amount of the carboxylate R(f)COO-M+. The essentially irreversible character of this process was shown experimentally and supported on the basis of DFT calculations. The synthesis of new acetyltrifluoroacetyl peroxides is also described. Reaction: see text.
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