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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Intrauterine correction of factor VIII (FVIII) deficiency

G S Gilchrist1, J L Wilke, L R Muehlenbein

  • 1Mayo Comprehensive Haemophilia Centre, Division of Paediatric Haematology/Oncology, Mayo Clinic and Foundation, Mayo Medical School, Rochester, MN 55905, USA.

Haemophilia : the Official Journal of the World Federation of Hemophilia
|September 14, 2001
PubMed

This is the first published report documenting the successful use of intrauterine infusion of factor VIII (FVIII) in order to reduce the risk of intracranial haemorrhage in a foetus with documented haemophilia A. This approach provides another option for management of newborns with documented coagulation factor deficiency. The subsequent development of an inhibitor directed against FVIII is believed to be related to exposure to exogenous FVIII in the presence of an inversion mutation and not to the intrauterine procedure.

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