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Related Experiment Videos

Voltammetric determination of praziquantel in tablets and biological fluids.

M Rizk1, F Belal, F Ibrahim

  • 1Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt. phrfac@mum.mans.eun.eg

Arzneimittel-Forschung
|September 15, 2001
PubMed
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A new polarographic method accurately determines praziquantel in various forms, including biological fluids. This sensitive technique offers reliable quantification for pharmaceutical and clinical applications.

Area of Science:

  • Analytical Chemistry
  • Electrochemistry

Background:

  • Praziquantel is a crucial anthelmintic drug.
  • Accurate quantification of praziquantel is essential for therapeutic drug monitoring and quality control.

Purpose of the Study:

  • To develop and validate a simple, sensitive, and reliable polarographic method for praziquantel determination.
  • To apply the method to pure praziquantel, tablet formulations, and biological samples.

Main Methods:

  • Utilized polarography with a dropping mercury electrode (DME) in Britton Robinson buffers (pH 7-12).
  • Employed direct current (DCt), differential pulse polarographic (DPP), and alternating current (ACt) modes.
  • Characterized the electrochemical behavior, including irreversibility, diffusion control, and adsorption properties.

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Main Results:

  • A well-defined cathodic wave was observed.
  • Linear current-concentration relationships were established across different concentration ranges for DCt, DPP, and ACt.
  • Achieved low detection limits: 0.32 µg/mL (DPP) and 0.02 µg/mL (ACt).
  • Demonstrated high accuracy and precision with average recoveries of 99.33% in urine and 98.23% in plasma.

Conclusions:

  • The proposed polarographic method is simple, sensitive, and suitable for determining praziquantel.
  • The method is effective for analyzing praziquantel in pure form, pharmaceutical formulations, and biological matrices.
  • Offers a viable alternative to existing analytical techniques for praziquantel quantification.