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Related Experiment Videos

Escape from vasoconstriction in the gastric microcirculation.

P H Guth, E Smith

    The American Journal of Physiology
    |June 1, 1975
    PubMed
    Summary

    Gastric submucosal arterioles show an "escape phenomenon," relaxing after initial constriction from nerve stimulation or norepinephrine. This suggests blood flow regulation involves vessel relaxation, not shunt opening.

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    Area of Science:

    • Physiology
    • Gastrointestinal Physiology
    • Microcirculation

    Background:

    • Splanchic resistance vessels escaping vasoconstriction was previously attributed to submucosal arteriovenous shunts.
    • This mechanism was hypothesized to increase submucosal blood flow during adrenergic stimulation.

    Purpose of the Study:

    • To investigate the mechanism of escape from vasoconstriction in the rat gastric microcirculation.
    • To determine if submucosal arteriovenous shunts are responsible for increased submucosal blood flow during adrenergic stimulation.

    Main Methods:

    • In vivo microscopy was used to observe rat gastric submucosal arterioles (13-33 µm).
    • Vessel responses were measured during left splanchnic nerve stimulation, norepinephrine, and vasopressin superfusion.
    • An image-splitting TV microscope recording system was employed.

    Main Results:

    • All stimuli initially caused vasoconstriction in gastric submucosal arterioles.
    • Escape from vasoconstriction occurred in all rats following nerve stimulation and norepinephrine superfusion.
    • Escape was observed in only one of five rats treated with vasopressin; no shunts were visualized.

    Conclusions:

    • Rat gastric submucosal arterioles exhibit an autoregulatory escape phenomenon.
    • The findings suggest that 'autoregulatory escape' in splanchnic beds results from vessel relaxation, not shunt recruitment.
    • This challenges the traditional hypothesis involving arteriovenous shunts in splanchnic blood flow regulation.

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