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[Influence of androgens on cardiovascular system in men]

W Barud1, R Palusiński, J Hanzlik

  • 1I Katedry i Kliniki Chorób Wewnetrznych Akademii Medycznej w Lublinie.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|September 15, 2001
PubMed

Insights

Androgens, hormones more prevalent in men, may offer protective effects against atherosclerosis despite higher coronary artery disease rates in males. This review explores androgen metabolism and cardiovascular impacts.

Area of Science:

  • Endocrinology
  • Cardiovascular Science
  • Molecular Biology

Context:

  • Coronary artery disease (CAD) exhibits higher morbidity and mortality in men compared to women.
  • Experimental and clinical research has extensively investigated the role of androgens in cardiovascular pathology.
  • The precise clinical implications of androgen deficiency and their molecular mechanisms remain incompletely understood.

Purpose:

  • To review the current understanding of androgen metabolism.
  • To elucidate the effects of androgens on the cardiovascular system.
  • To explore the relationship between androgens and major atherosclerosis risk factors.

Summary:

  • This review synthesizes evidence on androgen metabolism, their cardiovascular effects, and links to atherosclerosis risk factors.
  • While CAD is more common in men, androgens may possess protective properties against atherosclerosis.
  • The discussion covers molecular mechanisms and clinical implications of androgen action in cardiovascular health.

Impact:

  • Provides a comprehensive overview of androgens' role in cardiovascular health and disease.
  • Highlights potential therapeutic avenues related to androgen modulation for atherosclerosis prevention.
  • Informs future research directions on androgen deficiency and cardiovascular pathology.

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