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Outcomes of botulinum toxin treatment for patients with spasmodic dysphonia.

M S Benninger1, G Gardner, C Grywalski

  • 1Department of Otolaryngology-Head and Neck Surgery, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202, USA. Mbenning@HFHS.org

Archives of Otolaryngology--Head & Neck Surgery
|September 15, 2001
PubMed
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Spasmodic dysphonia (SD) significantly impacts quality of life. Botulinum toxin treatment led to substantial improvements in voice-related physical, functional, and emotional well-being for SD patients.

Area of Science:

  • Neurology
  • Otolaryngology
  • Speech-Language Pathology

Background:

  • Spasmodic dysphonia (SD) is a focal laryngeal dystonia causing communication difficulties.
  • The impact of SD on patients' quality of life remains inadequately quantified.

Purpose of the Study:

  • To evaluate the quality of life impact of SD using the Voice Handicap Index (VHI).
  • To assess the efficacy of botulinum toxin treatment on improving quality of life in SD patients.

Main Methods:

  • The VHI, a validated voice-specific instrument, was administered to 30 SD patients pre- and post-botulinum toxin treatment.
  • The VHI assesses physical, functional, and emotional impact subscales and a total score.
  • Pre- and post-treatment VHI scores were statistically compared.

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Main Results:

  • Pre-treatment VHI scores indicated significant physical (25.5), functional (21.4), and emotional (20.4) impairment, with a total score of 67.6.
  • Following botulinum toxin treatment, 22 patients showed statistically significant improvements across all VHI subscales and the total score (P=.001).

Conclusions:

  • Spasmodic dysphonia substantially affects patients' perceived quality of life.
  • Botulinum toxin treatment yields significant improvements in the VHI scores, enhancing quality of life for individuals with SD.