GABA(A) receptor beta2/beta3 subunit and GAD67 immunoreactivity in the trigeminal motor nucleus during early
J E Turman1, R A Rich, S H Chandler
1Department of Biokinesiology and Physical Therapy, University of Southern California, 1540 Alcazar St., CHP155 Los Angeles, CA 90089, USA. turman@hsc.usc.edu
Abstract:
GABA neurotransmission plays a role in brainstem circuitry responsible for jaw movements. We investigated the developmental relationship between terminals expressing GAD67 and GABA(A) receptor beta(2)/beta(3) subunit expression within the trigeminal motor nucleus. GAD67 immunoreactivity was intense throughout development. Neuropilar beta(2)/beta(3) immunoreactivity emerged during the 2nd postnatal week. Our data provide anatomical evidence for a GABAergic innervation of neonatal trigeminal motoneurons and suggest that beta(2)/beta(3) subunit expression is developmentally regulated in trigeminal motoneurons.
