Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 10, 2026

A Procedure to Observe Context-induced Renewal of Pavlovian-conditioned Alcohol-seeking Behavior in Rats

A Procedure to Observe Context-induced Renewal of Pavlovian-conditioned Alcohol-seeking Behavior in Rats

Published on: September 19, 2014

Measuring ethanol-seeking behavior: the effect of using repeated extinction trials.

H H Samson¹, A Chappell, C Czachowski

¹Center for the Neurobehavioral Study of Alcohol, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1083, USA. hsamson@wfubmc.edu

Alcohol (Fayetteville, N.Y.)

|September 15, 2001

Summary

This study developed a reliable method to measure ethanol-seeking behavior in rats. Repeated extinction tests effectively assessed seeking levels, aiding research into craving and potential treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Inclusive Search for Anomalous Single-Photon Production in MicroBooNE.

Physical review letters·2026

Same author

First Search for Dark Sector e^{+}e^{-} Explanations of the MiniBooNE Anomaly at MicroBooNE.

Physical review letters·2026

Same author

First Measurement of Charged-Current Muon-Neutrino-Induced K^{+} Production on Argon Using the MicroBooNE Detector.

Physical review letters·2026

Same author

Search for an Anomalous Production of Charged-Current ν_{e} Interactions without Visible Pions across Multiple Kinematic Observables in MicroBooNE.

Physical review letters·2025

Same author

First Measurement of ν_{e} and ν[over ¯]_{e} Charged-Current Single Charged-Pion Production Differential Cross Sections on Argon Using the MicroBooNE Detector.

Physical review letters·2025

Same author

Enhancing pressurized esports performance: a pilot study on the combined effects of transcranial direct current stimulation and arousal reappraisal.

Anxiety, stress, and coping·2025

Area of Science:

Neuroscience
Behavioral Pharmacology
Animal Models of Addiction

Background:

Understanding ethanol craving is crucial for addiction research.
Existing models struggle to differentiate ethanol seeking from consumption.
A reliable measure of ethanol-seeking behavior is needed.

Purpose of the Study:

To evaluate repeated, single-session extinction tests for assessing ethanol-seeking behavior.
To determine if extinction tests can reliably measure the appetitive strength of ethanol.
To establish a method for examining pharmacological effects on ethanol seeking.

Main Methods:

Utilized an appetitive and consummatory ethanol self-administration procedure in rats.
Implemented repeated, single-session extinction tests.

More Related Videos

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

Published on: January 29, 2017

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Related Experiment Videos

Last Updated: Jul 10, 2026

A Procedure to Observe Context-induced Renewal of Pavlovian-conditioned Alcohol-seeking Behavior in Rats

A Procedure to Observe Context-induced Renewal of Pavlovian-conditioned Alcohol-seeking Behavior in Rats

Published on: September 19, 2014

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

Published on: January 29, 2017

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Compared extinction responding to a breakpoint procedure for appetitive strength.

Main Results:

Repeated extinction tests showed no significant carryover effects between trials with sufficient reinforced sessions.
Rats consumed an average of 0.80 g/kg of ethanol within 20 minutes during reinforced sessions.
Extinction responding levels were comparable to those obtained via a breakpoint procedure.

Conclusions:

Repeated extinction tests provide a valuable and reliable method for assessing ethanol-seeking behavior in animal models.
This method can differentiate seeking from consumption behaviors.
The approach is suitable for evaluating pharmacological interventions targeting ethanol seeking.