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Functionalized amino acid anticonvulsants: synthesis and pharmacological evaluation of conformationally restricted
A LeTiran1, J P Stables, H Kohn
1Department of Chemistry, University of Houston, TX 77204-5641, USA.
Bioorganic & Medicinal Chemistry
|September 15, 2001
Abstract:
Proven conformationally restricted analogues of anticonvulsant functionalized amino acids (FAAs) were prepared using short-range cyclizations and evaluated in pharmacological assays providing new information concerning the structural requirements for FAA function.