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Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
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Immunology. Long live the mature B cell--a baffling mystery resolved

T J Waldschmidt1, R J Noelle

  • 1Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA.

Science (New York, N.Y.)
|September 15, 2001
PubMed

What determines whether transitional B cells newly emerged from the bone marrow will differentiate further to become mature, long-lived, circulating B lymphocytes? In a Perspective, Waldschmidt and Noelle discuss new findings showing that the TNF family ligand BAFF and its receptor BAFF-R are crucial for selecting transitional B cells into the mature B cell pool (Thompson et al., Schiemann et al.).

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