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Allpyral: An appraisal.

D H Goodman, J Harris

    Annals of Allergy
    |July 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Allpyral, a pollen extract, contains minimal antigen due to faulty alum preparation. This method discards most nitrogenous material, resulting in a less potent product compared to traditional extracts.

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    Area of Science:

    • Allergology
    • Biochemistry
    • Immunology

    Background:

    • Pollen extracts are used in allergy treatments.
    • Conventional preparations utilize aqueous or glycerol bases.
    • The development of alternative extraction methods is ongoing.

    Purpose of the Study:

    • To evaluate the composition and preparation method of Allpyral.
    • To compare the antigenic content of Allpyral with conventional pollen extracts.
    • To identify potential issues in the Allpyral manufacturing process.

    Main Methods:

    • Chemical analysis of Allpyral composition.
    • Assessment of nitrogenous material absorption during extraction.
    • Comparison of Allpyral with aqueous and glycerol pollen preparations.

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    Main Results:

    • Alum in Allpyral absorbs only 25% of extracted nitrogenous material.
    • A significant portion of nitrogenous material is lost in the supernatant.
    • Allpyral exhibits a lower antigenic material content than conventional extracts.

    Conclusions:

    • Allpyral is based on a flawed preparation concept.
    • The injudicious use of alum leads to significant loss of antigenic material.
    • Allpyral is a less potent antigenic preparation compared to standard methods.