[Verrucarin A from conidia of Dendrodochium toxicum Pidopl. et Bilai]

A substance which was dyed blue by 4p-(nitrobenzyl)pyridine, that evidenced for its trichotecene nature, has been isolated in the crystalline form from conidia Dendrodochium toxicum Pidopl. et Bilai--roridine H producer. Thin-layer chromatography of the substance in three different systems, the well-known macrocyclic trichotecenes being used as standards, permitted it to be identified with verrucarine A. The substances possessed high biological activity with respect to the indicator test-culture Candida kefyr 900. No other compounds of trichotecene nature were found. Possible role of verrucarine A is discussed.