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[Synthesis of beta-H-phosphono-alpha-phosphonomethyl analogues of nucleoside 5'-diphosphates]
A V Ivanov1, M V Ias'ko, L A Aleksandrova
1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991 Russia. aivanov@yandex.ru
Bioorganicheskaia Khimiia
|September 18, 2001
Abstract:
Novel beta-H-phosphono-alpha-phosphonomethyl analogues of nucleoside 5'-diphosphates were synthesized by phosphonylation of 5'-O-phosphonomethylthymidine and 9-[2-phosphonomethyloxy)ethyl]adenine with sodium pyrophosphite. The structures of the resulting individual compounds were confirmed by NMR and UV spectroscopy.