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Updated: Aug 9, 2026

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
Published on: January 31, 2014
[Collagen denaturation enthalpy--nonlinear function of 4-hydroxyproline]
T V Burdzhanadze1, E I Tiktopulo
1Natishvili Institute of Experimental Morphology, Georgian Academy of Sciences, Tbilisi 59, 380059 Georgia.
Abstract:
The results of calorimetric measurements of denaturation of collagens with different imino acid content are reported. In contrast to the existing point of view that denaturation enthalpy is a linear function of 4-oxyproline content, a nonlinear dependence was revealed. It is suggested that the reason for the observed nonlinearity is triplets of the (Gly-Pro-Hyp) type. An increase of their content can cause a decrease in the denaturation enthalpy in accord with the water-bridge structure and due to the minimum enthalpy effect of stabilization of the triplets as compared to triplets of other type.
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