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[Selective cytostatic and cytotoxic effects of avermectins]
V A Driniaev1, V A Mosin, E B Krugliak
1Pharmbiomed Research Centre of Biology, Moscow.
Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
|September 18, 2001
Abstract:
A natural avermectin complex, aversectin C, was shown to be capable of exerting selective cytostatic effect. It killed proliferating neuroblastoma B 103 cells but was non-toxic for differentiated cells of this culture. The activity of aversectin C was related neither to activation of the GABA alpha-receptors nor to their blocking and was at a large extent due to the action of avermectin A1, a component of aversectin C.