Related Experiment Video
Updated: Aug 10, 2026
08:38
Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Mycophenolate mofetil monotherapy in liver transplantation
Lancet (London, England)
|September 18, 2001
Summary
Mycophenolate mofetil monotherapy improved renal failure in liver transplant patients but led to organ rejection. The trial was halted due to high rates of rejection, indicating risks associated with this immunosuppressive strategy.
Area of Science:
- Nephrology
- Transplantation Medicine
- Immunosuppression
Background:
- Chronic renal failure is a significant complication post-orthotopic liver transplantation.
- Calcineurin-inhibitor immunosuppressive therapy is frequently associated with nephrotoxicity.
Purpose of the Study:
- To evaluate mycophenolate mofetil monotherapy as an alternative for liver transplant recipients with calcineurin-inhibitor-induced renal failure.
Main Methods:
- A randomized controlled trial was conducted.
- Patients received mycophenolate mofetil monotherapy after calcineurin-inhibitor (ciclosporin or tacrolimus) cessation.
- Renal function and signs of rejection were monitored.
Main Results:
- Renal failure improved with reduced and stopped calcineurin-inhibitor doses.
- However, three out of five patients on mycophenolate mofetil monotherapy experienced organ rejection.
- Rejection events necessitated a second transplantation in affected patients.
Conclusions:
- While mycophenolate mofetil monotherapy may improve renal function, it carries a substantial risk of organ rejection in liver transplant recipients.
- This strategy may not be suitable for all patients requiring immunosuppression post-liver transplantation.
More Related Videos
Related Concept Videos
01:24Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...