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Related Experiment Videos

Quantitative differences in the cellular yield of two bronchial brushes.

E D Michaelson, S M Serafind

    The American Review of Respiratory Disease
    |August 1, 1975
    PubMed
    Summary

    This study compared two commercial bronchial brushes, finding significant differences in cell yield but not ciliated cell percentage. Proper brush selection is crucial for accurate cytologic diagnosis.

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    Area of Science:

    • Pulmonology
    • Cytopathology
    • Medical Devices

    Background:

    • Bronchial brushing is a common diagnostic technique in respiratory medicine.
    • The cellular yield of bronchial brushes can impact diagnostic accuracy.
    • Variability in brush design may affect specimen collection.

    Purpose of the Study:

    • To compare the cellular yield of two commercially available bronchial brushes.
    • To assess the percentage of ciliated cells obtained by each brush.
    • To determine the implications of cellular yield for cytologic diagnosis.

    Main Methods:

    • Tracheal brushing was performed on 45 patients and 13 dogs using bronchofiberscopy.
    • Cells were extracted from two types of commercial bronchial brushes.
    • Total cell count and ciliated cell percentage were quantified using a hemacytometer.

    Main Results:

    • A large and statistically significant difference in total cell count was observed between the two brushes.
    • No significant difference was found in the percentage of ciliated cells obtained.
    • Cellular yield varied considerably based on the brush type used.

    Conclusions:

    • The choice of bronchial brush significantly impacts the number of cells collected.
    • Higher cellular yield may increase the likelihood of a positive cytologic diagnosis.
    • Bronchial brushes should be evaluated for their cellular yield to optimize diagnostic procedures.

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