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Correlation with redox potentials and inhibitory effects on Epstein-Barr virus activation of azaanthraquinones
J Koyama1, I Morita, K Tagahara
1Kobe Pharmaceutical University, Higashinada, Japan. j-koyama@kobepharma-u.ac.jp
Chemical & Pharmaceutical Bulletin
|September 18, 2001
Abstract:
The redox potentials have been determined for nine azaanthraquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the azaanthraquinones on Epstein-Barr virus early antigen (EBV-EA) activation. It has further been shown that the correlation can be made better by introducing an electronic property, i.e., the atomic charge at O11 as an additional parameter.