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Published on: July 18, 2017
CT and MR imaging features of pyogenic ventriculitis
M B Fukui1, R L Williams, S Mudigonda
1Division of Neuroradiology, Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Background And Purpose:
Pyogenic ventriculitis is an uncommon manifestation of severe intracranial infection that might be clinically obscure. We hypothesized that determining characteristic imaging features of pyogenic ventriculitis in patients with appropriate risk factors might improve recognition of this severe infection.
Methods:
Review of the medical records from 1990 to 2000 revealed 17 cases (12 men, five women) that satisfied inclusion criteria of abscess (n = 3) and/or positive cultures or increased white cells and protein in ventricular (n = 12) or cisternal (n = 1) cerebrospinal fluid. In one case, the diagnosis of ventriculitis was based on the combination of bacterial growth in lumbar cerebrospinal fluid and follow-up imaging. Staphylococcus species and Enterobacter species were the most common organisms. Two neuroradiologists independently evaluated imaging studies for hydrocephalus, ventricular debris, periventricular attenuation or signal abnormality, ependymal enhancement, and signs of meningitis or abscess. Sixteen studies in 11 patients were performed after the intravenous administration of contrast material.
Results:
Ventricular debris was detected in 16 (94%) of 17 cases and was irregular in 13 (81%) of 16 cases. Hydrocephalus was present in 13 (76%) of 17 cases. Periventricular hyperintense signal was present in most (seven [78%] of nine) cases with MR imaging and was most conspicuous on fluid-attenuated inversion recovery sequences. Ependymal enhancement was detected in seven (64%) of 11 cases in which contrast material was administered. Signs of meningitis (eg, pial or duraarachnoid signal abnormality or enhancement) were present in 13 (76%) of 17 cases. Three cases had imaging signs of abscess.
Conclusion:
Ventricular debris was the most frequent sign of ventriculitis in this series. An irregular level was characteristic of debris in ventriculitis. Hydrocephalus and ependymal enhancement were less frequent signs. Detection of ventricular debris might facilitate diagnosis of pyogenic ventriculitis, a potentially fatal infection, and thus permit appropriate therapy.
Insights
Pyogenic ventriculitis, a severe brain infection, is often hard to diagnose. Key imaging findings like ventricular debris can help identify this dangerous condition early for prompt treatment.
Area of Science:
- Neurology
- Infectious Diseases
- Radiology
Background:
- Pyogenic ventriculitis is a rare but severe intracranial infection.
- Its clinical presentation can be subtle, leading to diagnostic challenges.
Purpose of the Study:
- To identify characteristic imaging features of pyogenic ventriculitis.
- To improve the recognition of this severe infection in at-risk patients.
Main Methods:
- Retrospective review of 17 cases (1990-2000) with confirmed or suspected pyogenic ventriculitis.
- Independent evaluation of imaging studies (including MRI with contrast) for specific signs.
- Analysis of cerebrospinal fluid for infection markers.
Main Results:
- Ventricular debris was the most common finding (94%), often irregular.
- Hydrocephalus (76%) and meningitis signs (76%) were also frequent.
- Ependymal enhancement (64%) and periventricular signal abnormalities on MRI were noted.
Conclusions:
- Ventricular debris is a key imaging indicator for diagnosing pyogenic ventriculitis.
- Early detection through characteristic imaging findings can facilitate timely and appropriate therapy.
- Recognizing these imaging patterns is crucial for managing this potentially fatal infection.
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