Distribution of HEOD (dieldrin) in mammals: II. some applications of the preliminary model

The preliminary model of the lipid-phase pharmacokinetics of dieldrin in mammals is applied to evaluation of the probable role of auto-induction, the effect(s) of growth, and the role of compartmentalization. Realistic simulations and comparison to actual data permit the conclusion to be drawn that induction of its own metabolism plays a relatively monor role in the distribution and level of dieldrin residues. Although some of the effects of growth are resonably well simulated, the model as constructed does not permit compartmentalization. It was concluded that the model should be revised to include aspects of the as-yet quantitatively unknown intracellular binding and membrane transport within the flow-limited model.