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Fenofibrate-Induced elevation in serum creatinine.

J L Ritter1, S Nabulsi

  • 1Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois 60515, USA.

Pharmacotherapy
|September 19, 2001
PubMed
Summary
This summary is machine-generated.

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Fenofibrate, used for hyperlipidemia, may cause elevated serum creatinine. Routine monitoring is recommended to detect potential kidney function changes early.

Area of Science:

  • Pharmacology
  • Nephrology
  • Clinical Medicine

Background:

  • Fenofibrate is a fibric acid derivative prescribed for hyperlipidemia.
  • Common side effects include gastrointestinal issues and rare liver function test elevations.
  • Package inserts note potential for serum creatinine increases, but lack postmarketing reports.

Observation:

  • Six patients at our clinic experienced elevated serum creatinine levels.
  • Fenofibrate was identified as the likely cause in these cases.
  • This contrasts with the manufacturer's lack of reported postmarketing cases.

Findings:

  • Fenofibrate use was associated with probable elevations in serum creatinine.
  • The observed elevations were not previously documented in postmarketing surveillance.

Related Experiment Videos

  • This suggests a potential, underreported adverse effect of fenofibrate.

    • Implications:

    • Elevated serum creatinine can indicate serious kidney dysfunction.
    • Routine monitoring of serum creatinine is crucial for patients on fenofibrate.
    • Monitoring should occur at baseline and 1-2 months after initiating therapy.