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Effects of antileukotriene among asthmatic patients
1Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Study Objective:
To determine the effect of antileukotriene (montelukast) 10 mg once daily for the treatment of mild to moderate asthma.
Design:
Open label, prospective.
Patients:
Thirty asthmatic patients > or = 18 years of age with baseline FEV1 > 60 per cent and < or = 80 per cent of predicted values and evidence of reversible airway obstruction, as defined by an increase in FEV1 of > or = 20 per cent.
Interventions:
Montelukast 10 mg once daily orally for 12 weeks, back up beta-2 agonist inhaler was available.
Measurement And Results:
Spirometry was performed during the screening period, and every month after starting antileukotriene. Subjects recorded asthma-related symptoms and use of supplement beta-2 agonists daily on diary cards. Over 12 weeks of treatment, the FEV1 increased 10 per cent, 14 per cent and 19 per cent respectively, compared to the baseline (p < 0.05). The physician and patients evaluation scores were quite good in the study.
Conclusion:
Oral montelukast once daily gave a favorable effect in management of mild to moderate asthmatic patients.
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