Jove
Visualize
Contact Us

Related Experiment Videos

Small Intestinal Failure in Children.

Samuel Kocoshis1

  • 1Division of Gastroenterology and Nutrition, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. samuel.kocoshis@chmcc.org

Current Treatment Options in Gastroenterology
|September 19, 2001
PubMed
Summary

Optimizing parenteral nutrition (TPN) for children with intestinal failure involves ensuring adequate nutrition, minimizing nutrient loss, and promoting intestinal adaptation. Long-term TPN poses risks like sepsis and liver disease, necessitating careful management and consideration of intestinal transplantation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quality of life for pediatric patients with short bowel syndrome-associated intestinal failure treated with teduglutide.

Journal of pediatric gastroenterology and nutrition·2026
Same author

Care transition from a pediatric intestinal rehabilitation program to adult care and the risk of all-cause mortality: A retrospective cohort study.

JPEN. Journal of parenteral and enteral nutrition·2026
Same author

Parenteral nutrition weaning in pediatric intestinal failure patients enrolled in remote patient monitoring: A descriptive study.

JPEN. Journal of parenteral and enteral nutrition·2025
Same author

Long-term teduglutide associated with improved response in pediatric short bowel syndrome-associated intestinal failure.

Journal of pediatric gastroenterology and nutrition·2024
Same author

Pediatric Intestinal Transplantation Management and Outcomes.

NeoReviews·2023
Same author

Operational tolerance after pediatric composite liver-pancreas-intestine transplantation following severe graft-versus-host disease.

Pediatric transplantation·2021
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Pediatric Gastroenterology
  • Intestinal Failure Management
  • Parenteral Nutrition

Background:

  • Children with intestinal failure require specialized care focused on nutrition, fluid balance, and gut adaptation.
  • Long-term parenteral nutrition (TPN) presents significant challenges, including sepsis, central line complications, and cholestatic liver disease.
  • Minimizing fecal losses and promoting intestinal adaptation are crucial but often difficult to achieve.

Purpose of the Study:

  • To outline the primary goals in managing pediatric intestinal failure.
  • To discuss the challenges and strategies associated with each management goal.
  • To highlight the role of intestinal transplantation when other treatments fail.

Main Methods:

  • Review of current therapeutic strategies for pediatric intestinal failure.

Related Experiment Videos

  • Discussion of short- and long-term complications of parenteral nutrition.
  • Evaluation of medical, surgical, and transplantation-based interventions.

    • Main Results:

    • Parenteral nutrition (TPN) can sustain nutrition short-term but carries long-term risks.
    • Minimizing fecal losses is partially achievable with medications and antibiotics for bacterial overgrowth.
    • Intestinal adaptation can be enhanced in select cases through luminal nutrition and surgical interventions.
    • Intestinal transplantation is a viable option for irreversible complications.

    Conclusions:

    • Effective management of pediatric intestinal failure requires a multi-faceted approach addressing nutrition, fluid balance, and gut adaptation.
    • Careful monitoring and management are essential to mitigate the risks associated with long-term TPN.
    • Intestinal transplantation should be considered for patients with irreversible TPN-associated complications.