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Ergotism.

L G Henry, J S Blackwood, J E Conley

    Archives of Surgery (Chicago, Ill. : 1960)
    |August 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Ergot medications for headache relief can cause severe extremity ischemia. Discontinuing the ergot medication often reverses the condition, with angiography confirming arterial spasm as the cause.

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    Area of Science:

    • Vascular Medicine
    • Neurology
    • Pharmacology

    Background:

    • Methysergide maleate and ergot are medications historically used for headache relief.
    • Vascular complications associated with these medications are not widely recognized.

    Purpose of the Study:

    • To report cases of severe extremity ischemia linked to ergot ingestion.
    • To highlight the diagnostic utility of angiography in identifying arterial spasm.

    Main Methods:

    • Case series of four patients presenting with severe extremity ischemia.
    • Clinical assessment, medication history review, and angiography.

    Main Results:

    • Four patients developed severe extremity ischemia after ingesting methysergide maleate or ergot for headache.

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  • Ischemia affected both upper and lower extremities.
  • Angiography revealed arterial spasm, confirming ergot as the likely cause.

    • Conclusions:

    • Ergot ingestion can precipitate severe extremity ischemia.
    • Discontinuation of the offending agent is often sufficient for recovery.
    • Angiography is a valuable diagnostic tool for identifying ergot-induced arterial spasm.