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Serum prognostic indicators in experimental Bacteroides peritonitis.
Archives of Surgery (Chicago, Ill. : 1960)
|September 1, 1975
Summary
Serum lysozyme levels increased significantly in dogs with Bacteroides peritonitis, especially nonsurvivors, indicating potential for monitoring antibiotic efficacy and prognosis.
Area of Science:
- Veterinary Medicine
- Immunology
- Microbiology
Background:
- Bacteroides peritonitis is a serious condition in dogs.
- Understanding immune responses is crucial for treatment.
- Hemolytic complement (CH100) and lysozyme are key immune components.
Purpose of the Study:
- To investigate serum lysozyme and CH100 levels in dogs with experimental Bacteroides peritonitis.
- To assess the correlation of these levels with survival and antibiotic treatment efficacy.
Main Methods:
- Experimental induction of Bacteroides peritonitis in dogs.
- Measurement of serum lysozyme and CH100 levels at various time points.
- Comparison of levels between surviving and nonsurviving animals.
- Evaluation of the impact of antibiotic therapy on these immune markers.
Main Results:
- CH100 levels showed minimal changes in survivors but decreased moderately in nonsurvivors.
- Lysozyme levels initially decreased in all dogs, then increased.
- Nonsurvivors exhibited a threefold increase in lysozyme before death.
- Antibiotic therapy did not significantly alter CH100 levels but resulted in milder lysozyme elevations compared to untreated dogs.
Conclusions:
- Serum lysozyme levels may serve as a valuable indicator of antibiotic efficacy in Bacteroides peritonitis.
- Elevated lysozyme levels correlate with a poor prognosis and impending death.
- Monitoring lysozyme offers insights into disease progression and treatment response in canine peritonitis.