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Related Experiment Videos

Blood histamine levels after exercise testing.

M G Harries, P S Burge, I O'Brien

    Clinical Allergy
    |September 1, 1979
    PubMed
    Summary
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    Exercise increases histamine and basophil counts in whole blood for both asthmatics and controls. Plasma histamine only rose in one asthmatic patient who developed exercise-induced urticaria.

    Area of Science:

    • Exercise physiology
    • Immunology
    • Allergy research

    Background:

    • Histamine is a key mediator in allergic reactions and inflammation.
    • Exercise can trigger physiological changes, including immune responses.
    • Asthma involves airway inflammation and hypersensitivity.

    Purpose of the Study:

    • To investigate histamine levels in whole blood and plasma after exercise in asthmatics and healthy individuals.
    • To explore the relationship between exercise, histamine, and basophil counts.
    • To determine if plasma histamine changes are associated with exercise-induced reactions like urticaria.

    Main Methods:

    • Blood samples (whole blood and plasma) were collected from 23 subjects (17 asthmatics, 6 controls).
    • Subjects underwent exercise testing.

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  • Histamine levels and basophil counts were measured in blood samples.

    • Main Results:

    • Whole blood histamine levels increased in both asthmatic and control groups post-exercise.
    • The rise in whole blood histamine correlated with an increase in basophil count.
    • Plasma histamine levels did not significantly increase, except in one asthmatic patient who developed urticaria.

    Conclusions:

    • Exercise induces a systemic release of histamine into whole blood, linked to basophil activity, in both asthmatics and controls.
    • Peripheral plasma histamine elevation is not a consistent finding after exercise, even in asthmatics.
    • The single case of plasma histamine rise and urticaria suggests a specific, severe reaction rather than a general response to exercise.