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Diagnostic radiation and the risk of multiple myeloma (United States)
J L Hatcher1, D Baris, A F Olshan
1Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, USA. jhatcher@childtrends.org
Objective:
To evaluate the relationship between cumulative lifetime exposure to diagnostic radiation and the risk of multiple myeloma using data from a large, multi-center, population-based case-control study.
Methods:
Study subjects included a total of 540 cases with newly diagnosed multiple myeloma and 1998 frequency-matched population controls living in three areas of the United States (Georgia, Michigan, New Jersey). Information on exposure to diagnostic X-rays was obtained by personal interview.
Results:
No association was found between case-control status and the total number of reported diagnostic X-rays of any type (odds ratio (OR) for 20 or more compared to less than 5 X-rays = 0.9, 95% confidence interval (95% CI) = 0.7-1.2). There was no evidence of an excess risk of multiple myeloma among individuals who reported exposure to 10 or more diagnostic X-rays that impart a relatively high radiation dose to the bone marrow, as compared to individuals reporting no such exposures (OR 0.7, 95% CI 0.4-1.3).
Conclusions:
These data suggest that exposure to diagnostic X-rays has a negligible impact, if any, on risk of developing multiple myeloma.
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