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Synthesis and terminal functionalization of a polymerizable phosphatidylethanolamine
1Laboratory for Biomolecular Materials Research, Department of Surgery and Bioengineering, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Bioconjugate Chemistry
|September 20, 2001
Abstract:
We report the design and synthesis of bifunctional phospholipid conjugates, which contain a polymerizable acrylate group and a terminal linker, such as biotin or N-(epsilon-maleimidocaproyl (EMC), to facilitate bioconjugation reactions. The lipid conjugate can be used to generate a multifunctional substrate-supported phospholipid film that is further stabilized via in-situ photocopolymerization.