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Serum creatine kinase BB linked to immunoglobulin G
Clinica Chimica Acta; International Journal of Clinical Chemistry
|September 15, 1979
Summary
Researchers identified an unusual form of creatine kinase (CK) in a patient's blood after a heart attack. This macro creatine kinase (Macro CK) was found to be a complex of CK-BB isoenzyme and immunoglobulin G.
Area of Science:
- Biochemistry
- Clinical Chemistry
- Immunology
Background:
- Creatine kinase (CK) is a crucial enzyme in cellular energy metabolism.
- CK isoenzymes (CK-MM, CK-MB, CK-BB) are routinely analyzed for diagnosing conditions like myocardial infarction.
- Atypical forms of CK, such as Macro CK, can complicate diagnostic interpretations.
Observation:
- An atypical creatine kinase fraction was detected in the serum of a female patient post-myocardial infarction.
- Electrophoresis revealed a unique band migrating between CK-MM and CK-MB isoenzymes.
- Ion-exchange chromatography isolated this atypical CK, along with CK-BB, from eluted fractions.
Findings:
- Immunological investigations and exclusion chromatography confirmed the atypical CK as high molecular mass complexes.
- These complexes were identified as being formed by the CK-BB isoenzyme bound to immunoglobulin G (IgG).
- This Macro CK represents a specific biochemical finding in the patient's serum.
Implications:
- The presence of Macro CK (CK-BB/IgG complexes) may require specific diagnostic considerations.
- Understanding the formation of these complexes is important for accurate enzyme analysis.
- Further research is needed to determine the clinical significance and prevalence of this Macro CK variant.