Related Experiment Video
Updated: Oct 4, 2026

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
Published on: November 21, 2017
Therapeutic moderate hypothermia and fever
1Department of Neurological Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA. dmarion@neuronet.pitt.edu
Abstract:
Fever above 38 degrees C that occurs in patients with acute neurosurgical diseases appears to worsen secondary brain injury and ultimate neurologic outcomes. Laboratory investigations are quite clear regarding the adverse effects of fever in terms not only of functional outcomes, but also histologic and neurochemical injury. Several preliminary clinical studies also suggest worsened neurologic outcomes in patients who are febrile compared to those who are not. Unfortunately, however, a large prospective study of 428 patients with acute neurosurgical diseases has shown that fever is extraordinarily common during the first seven days after subarachnoid hemorrhage, stroke, and TBI. The ability to eliminate fever in most of these patients during the first five to seven days after their injury would seem desirable. Based on a phase-I trial, it appears that intravascular cooling is a promising new method for avoiding fever in the neurosurgical ICU.
More Related Videos
Related Concept Videos
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Increased Body Temperature
Decreased Body Temperature
Homeostatic Imbalances in Body Temperature
Patterns of Fever
Factors Affecting Body Temperature
Factors may include:

