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Updated: Aug 8, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
[Fever of central origin during stroke]
A Morales-Ortiz1, M Jiménez-Pascual, J A Pérez-Vicente
1Sección de Neurología; Hospital Santa María del Rosell, Cartagena, 30203, España. amoraleso@meditex.es
Revista De Neurologia
|September 20, 2001
Summary
Fever after stroke is common. A subset of patients experienced central fever, characterized by earlier onset, higher severity, and poorer response to treatment, suggesting distinct clinical features.
Area of Science:
- Neurology
- Internal Medicine
- Critical Care
Background:
- Fever occurs in approximately 25% of stroke patients.
- The origin of fever is often infectious but can be unknown in some cases.
- Central mechanisms, such as hypothalamic lesions, are hypothesized to cause fever post-stroke.
Purpose of the Study:
- To determine the frequency of central fever in stroke patients.
- To identify clinical differences between infectious and central fever origins.
Main Methods:
- Prospective evaluation of 103 stroke patients.
- Investigation for infectious origins in febrile patients.
- Categorization into "infectious fever" and "fever without infection documented" groups for comparative analysis.
Main Results:
- 23% of patients experienced fever; 33% of these had no documented infection (suggesting central fever).
- Central fever cases presented earlier, with greater clinical severity and mortality.
- Higher fever temperatures and reduced response to antipyretics were observed in the central fever group.
Conclusions:
- Fever without documented infection in stroke patients exhibits a distinct clinical profile.
- These findings suggest a specific pattern for central fever, differentiating it from infectious fever post-stroke.
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01:25Increased Body Temperature
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
01:25Types of Fever
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