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[Peripheral neuropathy in systemic lupus erythematosus]
I Campello1, C Almárcegui, J Velilla
1Unidad de Neurología; Fundación Hospital de Manacor, Manacor, 07500, España. icampello@hospitalmanacor.org
Revista De Neurologia
|September 20, 2001
Summary
Subclinical peripheral neuropathy affects half of patients with Systemic Lupus Erythematosus (SLE), often without noticeable symptoms. Early neurophysiological studies are crucial for detection due to a lack of associated clinical markers.
Area of Science:
- Rheumatology
- Neurology
- Clinical Medicine
Context:
- Systemic Lupus Erythematosus (SLE) is a connective tissue disease frequently associated with neuropsychiatric issues.
- Peripheral neuropathy prevalence in SLE ranges from 5-27%, with subclinical forms being common.
Purpose:
- To ascertain the prevalence of subclinical peripheral neuropathy in SLE patients.
- To characterize these neuropathies and explore associations with clinical and analytical disease parameters.
Summary:
- Neurophysiological studies revealed peripheral neuropathy in 50% of SLE patients, predominantly asymptomatic (75%) and neurologically normal on examination (81.2%).
- The most common type was axonal, symmetrical, sensomotor polyneuropathy (37.5%), followed by mononeuropathies (6.2% each).
- No significant associations were found between peripheral neuropathy and clinical or analytical SLE parameters.
Impact:
- Highlights the high frequency of subclinical peripheral neuropathy in SLE.
- Underscores the necessity of neurophysiological testing for early detection and management in SLE patients.
- Emphasizes the lack of clear clinical indicators for peripheral neuropathy in SLE.