Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute mountain sickness: increased severity in eucapnic hypoxia.

J T Maher, A Cymerman, J T Reeves

    Aviation, Space, and Environmental Medicine
    |June 1, 1975
    PubMed
    Summary

    Preventing hypocapnia (low CO2) did not alleviate acute mountain sickness (AMS) symptoms. Normocapnic subjects experienced more severe AMS than hypocapnic subjects, suggesting CO2 addition may worsen symptoms at high altitude.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Indicator-based sustainability assessment of poultry litter ash (PLA) as a supplementary cementitious material using an AHP-TOPSIS-RSM framework.

    Environmental research·2026
    Same author

    Application of nanosilica in the construction industry: A bibliometric analysis using <i>Methodi Ordinatio</i>.

    MethodsX·2024
    Same author

    Does chlorhexidine reduce the incidence of ventilator-associated pneumonia in ICU patients? A systematic review and meta-analysis.

    Medicina intensiva·2022
    Same author

    Effects of Hyperosmolality on Hypothalamic Astrocytic Area, mRNA Expression and Glutamate Balance In Vitro.

    Neuroscience·2020
    Same author

    Post-transcriptional silencing of the SGE1 gene induced by a dsRNA hairpin in Fusarium oxysporum f. sp cubense, the causal agent of Panama disease.

    Genetics and molecular research : GMR·2016
    Same author

    OSL and TL response characterization of LiF:MG,Ti microdosimeters to be applied to VMAT quality assurance.

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2015

    Area of Science:

    • Physiology
    • Altitude Medicine
    • Environmental Health

    Background:

    • Acute mountain sickness (AMS) is a common condition at high altitudes.
    • The role of hypocapnia and alkalosis in AMS pathophysiology is debated.
    • Previous studies suggested CO2 supplementation might alleviate AMS symptoms.

    Purpose of the Study:

    • To test the hypothesis that preventing hypocapnia and alkalosis would ameliorate AMS symptoms.
    • To investigate the effect of normocapnia versus hypocapnia on AMS severity under simulated high altitude conditions.

    Main Methods:

    • Five subjects were exposed to simulated high altitude with CO2 added to maintain normocapnia.
    • Four subjects were exposed to simulated high altitude without CO2, resulting in hypocapnia.

    Related Experiment Videos

  • Alveolar oxygen tensions were kept comparable between groups by adjusting barometric pressure.

    • Main Results:

    • Normocapnic subjects exhibited greater AMS symptom severity compared to hypocapnic subjects.
    • Prevention of hypocapnia did not alleviate AMS symptoms.
    • CO2 addition in comparably hypoxic groups augmented AMS symptoms, potentially due to increased cerebral vasodilation.

    Conclusions:

    • The hypothesis that preventing hypocapnia and alkalosis would ameliorate AMS was not supported.
    • CO2 supplementation may exacerbate AMS symptoms, contrary to some previous findings.
    • Findings suggest that hypocapnia might offer some protection against AMS, possibly through mechanisms other than hypoxia relief.