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Synthesis and antiviral activity of novel exomethylene cyclopropyl nucleosides
1Department of Medicinal Chemistry, College of Pharmacy, Chonnam National University, Kwangju 500-757, Korea.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
Novel cyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate 5, prepared from Feist's acid 1 was condensed with purine derivatives by the SN2 type reaction. All the synthesized compounds were evaluated for antiviral activity.