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Updated: Jul 24, 2026
15:22
Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Synthesis of modified nucleoside 5'-triphosphates for in vitro selection of catalytic nucleic acids
J Matulic-Adamic1, A T Daniher, A Karpeisky
1Department of Chemistry & Biochemistry, Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, Colorado 80301, USA.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
2'-Modified pyrimidine nucleoside 5'-triphosphates comprising amino, imidazole and carboxylate functionality attached to the 5-position of the base were synthesized. Two different phosphorylation methods were used to optimize the yields of these highly modified triphosphates.
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