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Synthesis and evaluation of prolyl carbamate nucleic acids (PrCNA)
1Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411008, India.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
Carbamate linked prolyl nucleic acids are obtained in high yield and purity under mild conditions in solution and solid phase. p-Nitrophenylchloroformate is used as the activating reagent for alcohol. Homooligomers of PrCNA do not bind to DNA. The introduction of this modification in PNA sequences destabilizes the triplexes, inspite of enhancement in the base stacking.